Both GLP and non-GLP biomarker assays are used to elucidate pharmacodynamics, mechanisms of action, and toxicity. The ever growing list of assays established at ITR Laboratories Canada now includes markers of inflammation, bone metabolism, endocrinology and cardiac toxicity.

Links to Biomarkers Rat
Links to Biomarkers Dog
Links to Biomarkers Monkey
Links to Biomarkers Other

PHARMACODYNAMICS

ITR Laboratories Canada has dedicated laboratories and made a commitment to fully support clients’ needs for pharmacodynamics biomarkers. This includes both in vitro and exvivo endpoints for drug potency.

Commonly these biomarkers are protein expression, signally pathway activation/inhibition, RNA expression or target knockdown.

FACILITIES INCLUDE:

LIGAND BINDING LAB:

  • Flow cytometer (BD FacsCanto II -2 lasers, 6 colors)
  • Multiple plate washers and readers (Both MolDev and Biotek)
  • All necessary support equipment

TISSUE CULTURE ROOM (BSL2, 2+):

  • Laminar flow hood, CO2 incubators
  • Microscopes with image capture systems
  • All necessary support equipment (cell banking, etc.)

MOLECULAR BIOLOGY LAB:

  • Tissue extraction (TissueLyzer, Polytron)
  • nucleic acid characterization (Agilent bioanalyzer)
  • QPCR (ViiA7) and TLDA