Both GLP and non-GLP biomarker assays are used to elucidate pharmacodynamics, mechanisms of action, and toxicity. The ever growing list of assays established at ITR Laboratories Canada now includes markers of inflammation, bone metabolism, endocrinology and cardiac toxicity.
ITR Laboratories Canada has dedicated laboratories and made a commitment to fully support clients’ needs for pharmacodynamics biomarkers. This includes both in vitro and exvivo endpoints for drug potency.
Commonly these biomarkers are protein expression, signally pathway activation/inhibition, RNA expression or target knockdown.